diff --git a/Marlin/Conditionals_LCD.h b/Marlin/Conditionals_LCD.h
index ae487e36c..c9d44b1be 100644
--- a/Marlin/Conditionals_LCD.h
+++ b/Marlin/Conditionals_LCD.h
@@ -505,4 +505,6 @@
 #define HAS_RESUME_CONTINUE (ENABLED(NEWPANEL) || ENABLED(EMERGENCY_PARSER))
 #define HAS_COLOR_LEDS (ENABLED(BLINKM) || ENABLED(RGB_LED) || ENABLED(RGBW_LED) || ENABLED(PCA9632) || ENABLED(NEOPIXEL_LED))
 
+#define USE_MARLINSERIAL !(defined(__AVR__) && defined(USBCON))
+
 #endif // CONDITIONALS_LCD_H
diff --git a/Marlin/MarlinConfig.h b/Marlin/MarlinConfig.h
index 47e6020d9..f0aa13044 100644
--- a/Marlin/MarlinConfig.h
+++ b/Marlin/MarlinConfig.h
@@ -30,7 +30,7 @@
 #include "Conditionals_LCD.h"
 #include "Configuration_adv.h"
 
-#if defined(__AVR__) && !defined(USBCON)
+#if USE_MARLINSERIAL
   #define HardwareSerial_h // trick to disable the standard HWserial
 #endif
 
diff --git a/Marlin/MarlinSerial.cpp b/Marlin/MarlinSerial.cpp
index cd4dd03ad..83bc49edc 100644
--- a/Marlin/MarlinSerial.cpp
+++ b/Marlin/MarlinSerial.cpp
@@ -34,7 +34,7 @@
 
 #include "MarlinConfig.h"
 
-#if !(defined(__AVR__) && defined(USBCON)) && (defined(UBRRH) || defined(UBRR0H) || defined(UBRR1H) || defined(UBRR2H) || defined(UBRR3H))
+#if USE_MARLINSERIAL && (defined(UBRRH) || defined(UBRR0H) || defined(UBRR1H) || defined(UBRR2H) || defined(UBRR3H))
 
   #include "MarlinSerial.h"
   #include "Marlin.h"
@@ -561,9 +561,9 @@
   // Preinstantiate
   MarlinSerial customizedSerial;
 
-#endif // !(__AVR__ && USBCON) && (UBRRH || UBRR0H || UBRR1H || UBRR2H || UBRR3H)
+#endif // USE_MARLINSERIAL && (UBRRH || UBRR0H || UBRR1H || UBRR2H || UBRR3H)
 
 // For AT90USB targets use the UART for BT interfacing
-#if defined(__AVR__) && defined(USBCON) && ENABLED(BLUETOOTH)
+#if !USE_MARLINSERIAL && ENABLED(BLUETOOTH)
   HardwareSerial bluetoothSerial;
 #endif
diff --git a/Marlin/MarlinSerial.h b/Marlin/MarlinSerial.h
index 9060f668a..96071f800 100644
--- a/Marlin/MarlinSerial.h
+++ b/Marlin/MarlinSerial.h
@@ -85,7 +85,7 @@
   #define TX_BUFFER_SIZE 32
 #endif
 
-#if !(defined(__AVR__) && defined(USBCON))
+#if USE_MARLINSERIAL
 
   #if RX_BUFFER_SIZE > 256
     typedef uint16_t ring_buffer_pos_t;
@@ -159,10 +159,10 @@
 
   extern MarlinSerial customizedSerial;
 
-#endif // !(__AVR__ && USBCON)
+#endif // USE_MARLINSERIAL
 
 // Use the UART for Bluetooth in AT90USB configurations
-#if defined(__AVR__) && defined(USBCON) && ENABLED(BLUETOOTH)
+#if !USE_MARLINSERIAL && ENABLED(BLUETOOTH)
   extern HardwareSerial bluetoothSerial;
 #endif
 
diff --git a/Marlin/Marlin_main.cpp b/Marlin/Marlin_main.cpp
index 2211bda88..08384b175 100644
--- a/Marlin/Marlin_main.cpp
+++ b/Marlin/Marlin_main.cpp
@@ -14500,15 +14500,14 @@ void loop() {
           card.closefile();
           SERIAL_PROTOCOLLNPGM(MSG_FILE_SAVED);
 
-          #if !(defined(__AVR__) && defined(USBCON))
+          #if USE_MARLINSERIAL
             #if ENABLED(SERIAL_STATS_DROPPED_RX)
               SERIAL_ECHOLNPAIR("Dropped bytes: ", customizedSerial.dropped());
             #endif
-
             #if ENABLED(SERIAL_STATS_MAX_RX_QUEUED)
               SERIAL_ECHOLNPAIR("Max RX Queue Size: ", customizedSerial.rxMaxEnqueued());
             #endif
-          #endif // !(__AVR__ && USBCON)
+          #endif
 
           ok_to_send();
         }
diff --git a/Marlin/SanityCheck.h b/Marlin/SanityCheck.h
index 6e7b62286..bf6d449cb 100644
--- a/Marlin/SanityCheck.h
+++ b/Marlin/SanityCheck.h
@@ -307,7 +307,7 @@
 /**
  * Serial
  */
-#if !(defined(__AVR__) && defined(USBCON))
+#if USE_MARLINSERIAL
   #if ENABLED(SERIAL_XON_XOFF) && RX_BUFFER_SIZE < 1024
     #error "SERIAL_XON_XOFF requires RX_BUFFER_SIZE >= 1024 for reliable transfers without drops."
   #elif RX_BUFFER_SIZE && (RX_BUFFER_SIZE < 2 || !IS_POWER_OF_2(RX_BUFFER_SIZE))
@@ -1274,7 +1274,7 @@ static_assert(X_MAX_LENGTH >= X_BED_SIZE && Y_MAX_LENGTH >= Y_BED_SIZE,
 /**
  * emergency-command parser
  */
-#if ENABLED(EMERGENCY_PARSER) && defined(__AVR__) && defined(USBCON)
+#if ENABLED(EMERGENCY_PARSER) && !USE_MARLINSERIAL
   #error "EMERGENCY_PARSER does not work on boards with AT90USB processors (USBCON)."
 #endif
 
diff --git a/Marlin/serial.h b/Marlin/serial.h
index dc1da8735..139f99c11 100644
--- a/Marlin/serial.h
+++ b/Marlin/serial.h
@@ -25,7 +25,10 @@
 
 #include "MarlinConfig.h"
 
-#if defined(__AVR__) && defined(USBCON)
+#if USE_MARLINSERIAL
+  #include "MarlinSerial.h"
+  #define MYSERIAL0 customizedSerial
+#else
   #include <HardwareSerial.h>
   #if ENABLED(BLUETOOTH)
     extern HardwareSerial bluetoothSerial;
@@ -33,9 +36,6 @@
   #else
     #define MYSERIAL0 Serial
   #endif // BLUETOOTH
-#else
-  #include "MarlinSerial.h"
-  #define MYSERIAL0 customizedSerial
 #endif
 
 extern const char echomagic[] PROGMEM;