diff --git a/Marlin/stepper.cpp b/Marlin/stepper.cpp
index 158e31dac..4026cc2ed 100644
--- a/Marlin/stepper.cpp
+++ b/Marlin/stepper.cpp
@@ -299,16 +299,14 @@ void Stepper::set_directions() {
     SET_STEP_DIR(Z); // C
   #endif
 
-  #if DISABLED(ADVANCE)
-    if (motor_direction(E_AXIS)) {
-      REV_E_DIR();
-      count_direction[E_AXIS] = -1;
-    }
-    else {
-      NORM_E_DIR();
-      count_direction[E_AXIS] = 1;
-    }
-  #endif //!ADVANCE
+  if (motor_direction(E_AXIS)) {
+    REV_E_DIR();
+    count_direction[E_AXIS] = -1;
+  }
+  else {
+    NORM_E_DIR();
+    count_direction[E_AXIS] = 1;
+  }
 }
 
 // "The Stepper Driver Interrupt" - This timer interrupt is the workhorse.
@@ -683,9 +681,6 @@ void Stepper::isr() {
     old_OCR0A += eISR_Rate;
     OCR0A = old_OCR0A;
 
-    #define SET_E_STEP_DIR(INDEX) \
-      E## INDEX ##_DIR_WRITE(e_steps[INDEX] <= 0 ? INVERT_E## INDEX ##_DIR : !INVERT_E## INDEX ##_DIR)
-
     #define START_E_PULSE(INDEX) \
       if (e_steps[INDEX]) E## INDEX ##_STEP_WRITE(INVERT_E_STEP_PIN)
 
@@ -695,17 +690,6 @@ void Stepper::isr() {
         E## INDEX ##_STEP_WRITE(!INVERT_E_STEP_PIN); \
       }
 
-    SET_E_STEP_DIR(0);
-    #if E_STEPPERS > 1
-      SET_E_STEP_DIR(1);
-      #if E_STEPPERS > 2
-        SET_E_STEP_DIR(2);
-        #if E_STEPPERS > 3
-          SET_E_STEP_DIR(3);
-        #endif
-      #endif
-    #endif
-
     // Step all E steppers that have steps
     for (uint8_t i = 0; i < step_loops; i++) {