diff --git a/Marlin/Conditionals_post.h b/Marlin/Conditionals_post.h
index edeec7e08..d37a9eb2e 100644
--- a/Marlin/Conditionals_post.h
+++ b/Marlin/Conditionals_post.h
@@ -724,7 +724,6 @@
 
   // Sensors
   #define HAS_FILAMENT_WIDTH_SENSOR (PIN_EXISTS(FILWIDTH))
-  #define HAS_FIL_RUNOUT (PIN_EXISTS(FIL_RUNOUT))
 
   // User Interface
   #define HAS_HOME (PIN_EXISTS(HOME))
diff --git a/Marlin/Configuration.h b/Marlin/Configuration.h
index d321fe128..ab86422aa 100644
--- a/Marlin/Configuration.h
+++ b/Marlin/Configuration.h
@@ -830,15 +830,16 @@
 #endif
 
 /**
- * Filament Runout Sensor
- * A mechanical or opto endstop is used to check for the presence of filament.
+ * Filament Runout Sensors
+ * Mechanical or opto endstops are used to check for the presence of filament.
  *
- * RAMPS-based boards use SERVO3_PIN.
- * For other boards you may need to define FIL_RUNOUT_PIN.
- * By default the firmware assumes HIGH = has filament, LOW = ran out
+ * RAMPS-based boards use SERVO3_PIN for the first runout sensor.
+ * For other boards you may need to define FIL_RUNOUT_PIN, FIL_RUNOUT2_PIN, etc.
+ * By default the firmware assumes HIGH=FILAMENT PRESENT.
  */
 //#define FILAMENT_RUNOUT_SENSOR
 #if ENABLED(FILAMENT_RUNOUT_SENSOR)
+  #define NUM_RUNOUT_SENSORS   1     // Number of sensors, up to one per extruder. Define a FIL_RUNOUT#_PIN for each.
   #define FIL_RUNOUT_INVERTING false // set to true to invert the logic of the sensor.
   #define FIL_RUNOUT_PULLUP          // Use internal pullup for filament runout pins.
   #define FILAMENT_RUNOUT_SCRIPT "M600"
diff --git a/Marlin/Marlin_main.cpp b/Marlin/Marlin_main.cpp
index 251bdcb1d..fcf5e2f81 100644
--- a/Marlin/Marlin_main.cpp
+++ b/Marlin/Marlin_main.cpp
@@ -924,15 +924,30 @@ void setup_killpin() {
 
 #if ENABLED(FILAMENT_RUNOUT_SENSOR)
 
-  void setup_filrunoutpin() {
-    #if ENABLED(ENDSTOPPULLUP_FIL_RUNOUT)
-      SET_INPUT_PULLUP(FIL_RUNOUT_PIN);
+  void setup_filament_runout_pins() {
+
+    #if ENABLED(FIL_RUNOUT_PULLUP)
+      #define INIT_RUNOUT_PIN(P) SET_INPUT_PULLUP(P)
     #else
-      SET_INPUT(FIL_RUNOUT_PIN);
+      #define INIT_RUNOUT_PIN(P) SET_INPUT(P)
+    #endif
+
+    INIT_RUNOUT_PIN(FIL_RUNOUT_PIN);
+    #if NUM_RUNOUT_SENSORS > 1
+      INIT_RUNOUT_PIN(FIL_RUNOUT2_PIN);
+      #if NUM_RUNOUT_SENSORS > 2
+        INIT_RUNOUT_PIN(FIL_RUNOUT3_PIN);
+        #if NUM_RUNOUT_SENSORS > 3
+          INIT_RUNOUT_PIN(FIL_RUNOUT4_PIN);
+          #if NUM_RUNOUT_SENSORS > 4
+            INIT_RUNOUT_PIN(FIL_RUNOUT5_PIN);
+          #endif
+        #endif
+      #endif
     #endif
   }
 
-#endif
+#endif // FILAMENT_RUNOUT_SENSOR
 
 void setup_powerhold() {
   #if HAS_SUICIDE
@@ -13289,6 +13304,38 @@ void disable_all_steppers() {
   disable_e_steppers();
 }
 
+#if ENABLED(FILAMENT_RUNOUT_SENSOR)
+
+  FORCE_INLINE bool check_filament_runout() {
+
+    if (IS_SD_PRINTING || print_job_timer.isRunning()) {
+
+      #if NUM_RUNOUT_SENSORS < 2
+        // A single sensor applying to all extruders
+        return READ(FIL_RUNOUT_PIN) == FIL_RUNOUT_INVERTING;
+      #else
+        // Read the sensor for the active extruder
+        switch (active_extruder) {
+          case 0: return READ(FIL_RUNOUT_PIN) == FIL_RUNOUT_INVERTING;
+          case 1: return READ(FIL_RUNOUT2_PIN) == FIL_RUNOUT_INVERTING;
+          #if NUM_RUNOUT_SENSORS > 2
+            case 2: return READ(FIL_RUNOUT3_PIN) == FIL_RUNOUT_INVERTING;
+            #if NUM_RUNOUT_SENSORS > 3
+              case 3: return READ(FIL_RUNOUT4_PIN) == FIL_RUNOUT_INVERTING;
+              #if NUM_RUNOUT_SENSORS > 4
+                case 4: return READ(FIL_RUNOUT5_PIN) == FIL_RUNOUT_INVERTING;
+              #endif
+            #endif
+          #endif
+        }
+      #endif
+
+    }
+    return false;
+  }
+
+#endif // FILAMENT_RUNOUT_SENSOR
+
 /**
  * Manage several activities:
  *  - Check for Filament Runout
@@ -13304,11 +13351,7 @@ void disable_all_steppers() {
 void manage_inactivity(bool ignore_stepper_queue/*=false*/) {
 
   #if ENABLED(FILAMENT_RUNOUT_SENSOR)
-    if ((IS_SD_PRINTING || print_job_timer.isRunning())
-       && READ(FIL_RUNOUT_PIN) == FIL_RUNOUT_INVERTING
-       && thermalManager.targetHotEnoughToExtrude(active_extruder)
-    )
-      handle_filament_runout();
+    if (check_filament_runout()) handle_filament_runout();
   #endif
 
   if (commands_in_queue < BUFSIZE) get_available_commands();
@@ -13615,7 +13658,7 @@ void setup() {
   #endif
 
   #if ENABLED(FILAMENT_RUNOUT_SENSOR)
-    setup_filrunoutpin();
+    setup_filament_runout_pins();
   #endif
 
   setup_killpin();
diff --git a/Marlin/SanityCheck.h b/Marlin/SanityCheck.h
index 704a63318..ec6f42c40 100644
--- a/Marlin/SanityCheck.h
+++ b/Marlin/SanityCheck.h
@@ -400,11 +400,21 @@ static_assert(X_MAX_LENGTH >= X_BED_SIZE && Y_MAX_LENGTH >= Y_BED_SIZE,
 #endif
 
 /**
- * Filament Runout needs a pin and either SD Support or Auto print start detection
+ * Filament Runout needs one or more pins and either SD Support or Auto print start detection
  */
 #if ENABLED(FILAMENT_RUNOUT_SENSOR)
-  #if !HAS_FIL_RUNOUT
+  #if !PIN_EXISTS(FIL_RUNOUT)
     #error "FILAMENT_RUNOUT_SENSOR requires FIL_RUNOUT_PIN."
+  #elif NUM_RUNOUT_SENSORS > E_STEPPERS
+    #error "NUM_RUNOUT_SENSORS cannot exceed the number of E steppers."
+  #elif NUM_RUNOUT_SENSORS > 1 && !PIN_EXISTS(FIL_RUNOUT2)
+    #error "FILAMENT_RUNOUT_SENSOR with NUM_RUNOUT_SENSORS > 1 requires FIL_RUNOUT2_PIN."
+  #elif NUM_RUNOUT_SENSORS > 2 && !PIN_EXISTS(FIL_RUNOUT3)
+    #error "FILAMENT_RUNOUT_SENSOR with NUM_RUNOUT_SENSORS > 2 requires FIL_RUNOUT3_PIN."
+  #elif NUM_RUNOUT_SENSORS > 3 && !PIN_EXISTS(FIL_RUNOUT4)
+    #error "FILAMENT_RUNOUT_SENSOR with NUM_RUNOUT_SENSORS > 3 requires FIL_RUNOUT4_PIN."
+  #elif NUM_RUNOUT_SENSORS > 4 && !PIN_EXISTS(FIL_RUNOUT5)
+    #error "FILAMENT_RUNOUT_SENSOR with NUM_RUNOUT_SENSORS > 4 requires FIL_RUNOUT5_PIN."
   #elif DISABLED(SDSUPPORT) && DISABLED(PRINTJOB_TIMER_AUTOSTART)
     #error "FILAMENT_RUNOUT_SENSOR requires SDSUPPORT or PRINTJOB_TIMER_AUTOSTART."
   #elif DISABLED(ADVANCED_PAUSE_FEATURE)