diff --git a/Marlin/Marlin_main.cpp b/Marlin/Marlin_main.cpp
index acd21369f..deb2bba6f 100644
--- a/Marlin/Marlin_main.cpp
+++ b/Marlin/Marlin_main.cpp
@@ -14284,13 +14284,15 @@ void loop() {
           card.closefile();
           SERIAL_PROTOCOLLNPGM(MSG_FILE_SAVED);
 
-          #if ENABLED(SERIAL_STATS_DROPPED_RX)
-            SERIAL_ECHOLNPAIR("Dropped bytes: ", customizedSerial.dropped());
-          #endif
+          #ifndef USBCON
+            #if ENABLED(SERIAL_STATS_DROPPED_RX)
+              SERIAL_ECHOLNPAIR("Dropped bytes: ", customizedSerial.dropped());
+            #endif
 
-          #if ENABLED(SERIAL_STATS_MAX_RX_QUEUED)
-            SERIAL_ECHOLNPAIR("Max RX Queue Size: ", customizedSerial.rxMaxEnqueued());
-          #endif
+            #if ENABLED(SERIAL_STATS_MAX_RX_QUEUED)
+              SERIAL_ECHOLNPAIR("Max RX Queue Size: ", customizedSerial.rxMaxEnqueued());
+            #endif
+          #endif // !USBCON
 
           ok_to_send();
         }
diff --git a/Marlin/SanityCheck.h b/Marlin/SanityCheck.h
index a38f1e8f7..75153c843 100644
--- a/Marlin/SanityCheck.h
+++ b/Marlin/SanityCheck.h
@@ -275,8 +275,8 @@
   #elif TX_BUFFER_SIZE && (TX_BUFFER_SIZE < 2 || TX_BUFFER_SIZE > 256 || !IS_POWER_OF_2(TX_BUFFER_SIZE))
     #error "TX_BUFFER_SIZE must be 0, a power of 2 greater than 1, and no greater than 256."
   #endif
-#elif ENABLED(SERIAL_XON_XOFF)
-  #error "SERIAL_XON_XOFF is not supported on USB-native AVR devices."
+#elif ENABLED(SERIAL_XON_XOFF) || ENABLED(SERIAL_STATS_MAX_RX_QUEUED) || ENABLED(SERIAL_STATS_DROPPED_RX)
+  #error "SERIAL_XON_XOFF and SERIAL_STATS_* features not supported on USB-native AVR devices."
 #endif
 
 /**