diff --git a/Marlin/Configuration.h b/Marlin/Configuration.h
index 8b084797dc..f52cb1b6e2 100644
--- a/Marlin/Configuration.h
+++ b/Marlin/Configuration.h
@@ -98,7 +98,7 @@
  *
  * :[-1, 0, 1, 2, 3, 4, 5, 6, 7]
  */
-#define SERIAL_PORT 0
+#define SERIAL_PORT -1
 
 /**
  * Serial Port Baud Rate