diff --git a/Marlin/src/inc/SanityCheck.h b/Marlin/src/inc/SanityCheck.h
index 802506f163..e8f390b5be 100644
--- a/Marlin/src/inc/SanityCheck.h
+++ b/Marlin/src/inc/SanityCheck.h
@@ -3797,6 +3797,10 @@ static_assert(_PLUS_TEST(4), "HOMING_FEEDRATE_MM_M values must be positive.");
   #error "LED_CONTROL_MENU requires an LCD controller that implements the menu."
 #endif
 
+#if ENABLED(CUSTOM_MENU_MAIN) && NONE(HAS_MARLINUI_MENU, TOUCH_UI_FTDI_EVE, TFT_LVGL_UI)
+  #error "CUSTOM_MENU_MAIN requires an LCD controller that implements the menu."
+#endif
+
 #if ENABLED(CASE_LIGHT_USE_NEOPIXEL) && DISABLED(NEOPIXEL_LED)
   #error "CASE_LIGHT_USE_NEOPIXEL requires NEOPIXEL_LED."
 #endif