diff --git a/.travis.yml b/.travis.yml
index 7e2edc7376..ec77fa9a64 100644
--- a/.travis.yml
+++ b/.travis.yml
@@ -66,7 +66,7 @@ script:
   - opt_enable REPRAP_DISCOUNT_SMART_CONTROLLER SDSUPPORT EEPROM_SETTINGS
   - opt_enable BLINKM PCA9632 RGB_LED NEOPIXEL_LED
   - opt_enable AUTO_BED_LEVELING_LINEAR Z_MIN_PROBE_REPEATABILITY_TEST DEBUG_LEVELING_FEATURE SKEW_CORRECTION SKEW_CORRECTION_FOR_Z SKEW_CORRECTION_GCODE
-  - opt_enable_adv FWRETRACT MAX7219_DEBUG LED_CONTROL_MENU
+  - opt_enable_adv FWRETRACT MAX7219_DEBUG LED_CONTROL_MENU CASE_LIGHT_ENABLE CASE_LIGHT_USE_NEOPIXEL
   - opt_set ABL_GRID_POINTS_X 16
   - opt_set ABL_GRID_POINTS_Y 16
   - opt_set_adv FANMUX0_PIN 53
diff --git a/Marlin/Configuration_adv.h b/Marlin/Configuration_adv.h
index 4fd14fe1c8..b5a4aa46ad 100644
--- a/Marlin/Configuration_adv.h
+++ b/Marlin/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/default/Configuration_adv.h b/Marlin/src/config/default/Configuration_adv.h
index 4fd14fe1c8..b5a4aa46ad 100644
--- a/Marlin/src/config/default/Configuration_adv.h
+++ b/Marlin/src/config/default/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/AlephObjects/TAZ4/Configuration_adv.h b/Marlin/src/config/examples/AlephObjects/TAZ4/Configuration_adv.h
index 2bbdc50650..8ce80807d0 100644
--- a/Marlin/src/config/examples/AlephObjects/TAZ4/Configuration_adv.h
+++ b/Marlin/src/config/examples/AlephObjects/TAZ4/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Anet/A6/Configuration_adv.h b/Marlin/src/config/examples/Anet/A6/Configuration_adv.h
index 467fa2943e..56d18e4256 100644
--- a/Marlin/src/config/examples/Anet/A6/Configuration_adv.h
+++ b/Marlin/src/config/examples/Anet/A6/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Anet/A8/Configuration_adv.h b/Marlin/src/config/examples/Anet/A8/Configuration_adv.h
index 9a1306d1e3..4445a2ab97 100644
--- a/Marlin/src/config/examples/Anet/A8/Configuration_adv.h
+++ b/Marlin/src/config/examples/Anet/A8/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Azteeg/X5GT/Configuration_adv.h b/Marlin/src/config/examples/Azteeg/X5GT/Configuration_adv.h
index bf1d97f95b..e49aa08a37 100644
--- a/Marlin/src/config/examples/Azteeg/X5GT/Configuration_adv.h
+++ b/Marlin/src/config/examples/Azteeg/X5GT/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/BQ/Hephestos/Configuration_adv.h b/Marlin/src/config/examples/BQ/Hephestos/Configuration_adv.h
index 6a3fcc1d3c..dde7b9ace9 100644
--- a/Marlin/src/config/examples/BQ/Hephestos/Configuration_adv.h
+++ b/Marlin/src/config/examples/BQ/Hephestos/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/BQ/Hephestos_2/Configuration_adv.h b/Marlin/src/config/examples/BQ/Hephestos_2/Configuration_adv.h
index 287d381055..80b293a6bb 100644
--- a/Marlin/src/config/examples/BQ/Hephestos_2/Configuration_adv.h
+++ b/Marlin/src/config/examples/BQ/Hephestos_2/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/BQ/WITBOX/Configuration_adv.h b/Marlin/src/config/examples/BQ/WITBOX/Configuration_adv.h
index 6a3fcc1d3c..dde7b9ace9 100644
--- a/Marlin/src/config/examples/BQ/WITBOX/Configuration_adv.h
+++ b/Marlin/src/config/examples/BQ/WITBOX/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Cartesio/Configuration_adv.h b/Marlin/src/config/examples/Cartesio/Configuration_adv.h
index db9dec08ab..880b84151b 100644
--- a/Marlin/src/config/examples/Cartesio/Configuration_adv.h
+++ b/Marlin/src/config/examples/Cartesio/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Creality/CR-10/Configuration_adv.h b/Marlin/src/config/examples/Creality/CR-10/Configuration_adv.h
index c520edad76..c825e9878b 100755
--- a/Marlin/src/config/examples/Creality/CR-10/Configuration_adv.h
+++ b/Marlin/src/config/examples/Creality/CR-10/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Creality/CR-10S/Configuration_adv.h b/Marlin/src/config/examples/Creality/CR-10S/Configuration_adv.h
index 8187e89269..81d4b597b0 100644
--- a/Marlin/src/config/examples/Creality/CR-10S/Configuration_adv.h
+++ b/Marlin/src/config/examples/Creality/CR-10S/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Creality/Ender/Configuration_adv.h b/Marlin/src/config/examples/Creality/Ender/Configuration_adv.h
index 310f55adc7..9fc0acfcd8 100644
--- a/Marlin/src/config/examples/Creality/Ender/Configuration_adv.h
+++ b/Marlin/src/config/examples/Creality/Ender/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Felix/Configuration_adv.h b/Marlin/src/config/examples/Felix/Configuration_adv.h
index 4482a1dc18..998231b19e 100644
--- a/Marlin/src/config/examples/Felix/Configuration_adv.h
+++ b/Marlin/src/config/examples/Felix/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/FolgerTech/i3-2020/Configuration_adv.h b/Marlin/src/config/examples/FolgerTech/i3-2020/Configuration_adv.h
index 6babccbe7a..3e15443355 100644
--- a/Marlin/src/config/examples/FolgerTech/i3-2020/Configuration_adv.h
+++ b/Marlin/src/config/examples/FolgerTech/i3-2020/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Infitary/i3-M508/Configuration_adv.h b/Marlin/src/config/examples/Infitary/i3-M508/Configuration_adv.h
index 11ae89238e..66c1937155 100644
--- a/Marlin/src/config/examples/Infitary/i3-M508/Configuration_adv.h
+++ b/Marlin/src/config/examples/Infitary/i3-M508/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/MakerParts/Configuration_adv.h b/Marlin/src/config/examples/MakerParts/Configuration_adv.h
index 0ac8497781..66d9022793 100644
--- a/Marlin/src/config/examples/MakerParts/Configuration_adv.h
+++ b/Marlin/src/config/examples/MakerParts/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Malyan/M150/Configuration_adv.h b/Marlin/src/config/examples/Malyan/M150/Configuration_adv.h
index 27059007be..46c2217c8f 100644
--- a/Marlin/src/config/examples/Malyan/M150/Configuration_adv.h
+++ b/Marlin/src/config/examples/Malyan/M150/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Malyan/M200/Configuration_adv.h b/Marlin/src/config/examples/Malyan/M200/Configuration_adv.h
index 1d073a2ff2..d833df27ea 100644
--- a/Marlin/src/config/examples/Malyan/M200/Configuration_adv.h
+++ b/Marlin/src/config/examples/Malyan/M200/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Micromake/C1/enhanced/Configuration_adv.h b/Marlin/src/config/examples/Micromake/C1/enhanced/Configuration_adv.h
index eb5c51d53f..ed4ca02d71 100644
--- a/Marlin/src/config/examples/Micromake/C1/enhanced/Configuration_adv.h
+++ b/Marlin/src/config/examples/Micromake/C1/enhanced/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Mks/Sbase/Configuration_adv.h b/Marlin/src/config/examples/Mks/Sbase/Configuration_adv.h
index 420ff19d91..d946bc4d25 100644
--- a/Marlin/src/config/examples/Mks/Sbase/Configuration_adv.h
+++ b/Marlin/src/config/examples/Mks/Sbase/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/RigidBot/Configuration_adv.h b/Marlin/src/config/examples/RigidBot/Configuration_adv.h
index 29aa37979c..120b0e380d 100644
--- a/Marlin/src/config/examples/RigidBot/Configuration_adv.h
+++ b/Marlin/src/config/examples/RigidBot/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/SCARA/Configuration_adv.h b/Marlin/src/config/examples/SCARA/Configuration_adv.h
index 39e1344bb4..59fa09e2d3 100644
--- a/Marlin/src/config/examples/SCARA/Configuration_adv.h
+++ b/Marlin/src/config/examples/SCARA/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Sanguinololu/Configuration_adv.h b/Marlin/src/config/examples/Sanguinololu/Configuration_adv.h
index 3b3dc829b5..66a1fe4b13 100644
--- a/Marlin/src/config/examples/Sanguinololu/Configuration_adv.h
+++ b/Marlin/src/config/examples/Sanguinololu/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/TheBorg/Configuration_adv.h b/Marlin/src/config/examples/TheBorg/Configuration_adv.h
index de627fc5f4..3eebc90111 100644
--- a/Marlin/src/config/examples/TheBorg/Configuration_adv.h
+++ b/Marlin/src/config/examples/TheBorg/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/TinyBoy2/Configuration_adv.h b/Marlin/src/config/examples/TinyBoy2/Configuration_adv.h
index 49869e00cb..74e3d1c50c 100644
--- a/Marlin/src/config/examples/TinyBoy2/Configuration_adv.h
+++ b/Marlin/src/config/examples/TinyBoy2/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/UltiMachine/Archim2/Configuration_adv.h b/Marlin/src/config/examples/UltiMachine/Archim2/Configuration_adv.h
index 776e3b0759..94f6b54d8a 100644
--- a/Marlin/src/config/examples/UltiMachine/Archim2/Configuration_adv.h
+++ b/Marlin/src/config/examples/UltiMachine/Archim2/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Velleman/K8200/Configuration_adv.h b/Marlin/src/config/examples/Velleman/K8200/Configuration_adv.h
index 212549f1c3..554618acfe 100644
--- a/Marlin/src/config/examples/Velleman/K8200/Configuration_adv.h
+++ b/Marlin/src/config/examples/Velleman/K8200/Configuration_adv.h
@@ -256,6 +256,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Velleman/K8400/Configuration_adv.h b/Marlin/src/config/examples/Velleman/K8400/Configuration_adv.h
index 8b619eeaaa..aec834b664 100644
--- a/Marlin/src/config/examples/Velleman/K8400/Configuration_adv.h
+++ b/Marlin/src/config/examples/Velleman/K8400/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/Wanhao/Duplicator 6/Configuration_adv.h b/Marlin/src/config/examples/Wanhao/Duplicator 6/Configuration_adv.h
index d5391f4755..073d5c9ce2 100644
--- a/Marlin/src/config/examples/Wanhao/Duplicator 6/Configuration_adv.h	
+++ b/Marlin/src/config/examples/Wanhao/Duplicator 6/Configuration_adv.h	
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 255   // Set default power-up brightness (0-255, requires PWM pin)
   #define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/delta/FLSUN/auto_calibrate/Configuration_adv.h b/Marlin/src/config/examples/delta/FLSUN/auto_calibrate/Configuration_adv.h
index 297793f1d2..97e1d9861c 100644
--- a/Marlin/src/config/examples/delta/FLSUN/auto_calibrate/Configuration_adv.h
+++ b/Marlin/src/config/examples/delta/FLSUN/auto_calibrate/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/delta/FLSUN/kossel/Configuration_adv.h b/Marlin/src/config/examples/delta/FLSUN/kossel/Configuration_adv.h
index b0fe1cbf82..babb137106 100644
--- a/Marlin/src/config/examples/delta/FLSUN/kossel/Configuration_adv.h
+++ b/Marlin/src/config/examples/delta/FLSUN/kossel/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/delta/FLSUN/kossel_mini/Configuration_adv.h b/Marlin/src/config/examples/delta/FLSUN/kossel_mini/Configuration_adv.h
index 50a8b30835..d16e7e6655 100644
--- a/Marlin/src/config/examples/delta/FLSUN/kossel_mini/Configuration_adv.h
+++ b/Marlin/src/config/examples/delta/FLSUN/kossel_mini/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/delta/generic/Configuration_adv.h b/Marlin/src/config/examples/delta/generic/Configuration_adv.h
index 50a8b30835..d16e7e6655 100644
--- a/Marlin/src/config/examples/delta/generic/Configuration_adv.h
+++ b/Marlin/src/config/examples/delta/generic/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/delta/kossel_mini/Configuration_adv.h b/Marlin/src/config/examples/delta/kossel_mini/Configuration_adv.h
index 50a8b30835..d16e7e6655 100644
--- a/Marlin/src/config/examples/delta/kossel_mini/Configuration_adv.h
+++ b/Marlin/src/config/examples/delta/kossel_mini/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/delta/kossel_pro/Configuration_adv.h b/Marlin/src/config/examples/delta/kossel_pro/Configuration_adv.h
index 0d85659ba5..3d32d052ac 100644
--- a/Marlin/src/config/examples/delta/kossel_pro/Configuration_adv.h
+++ b/Marlin/src/config/examples/delta/kossel_pro/Configuration_adv.h
@@ -248,6 +248,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/delta/kossel_xl/Configuration_adv.h b/Marlin/src/config/examples/delta/kossel_xl/Configuration_adv.h
index f6791da516..87b77e3243 100644
--- a/Marlin/src/config/examples/delta/kossel_xl/Configuration_adv.h
+++ b/Marlin/src/config/examples/delta/kossel_xl/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/gCreate/gMax1.5+/Configuration_adv.h b/Marlin/src/config/examples/gCreate/gMax1.5+/Configuration_adv.h
index cf4d9b0797..471a84e1f6 100644
--- a/Marlin/src/config/examples/gCreate/gMax1.5+/Configuration_adv.h
+++ b/Marlin/src/config/examples/gCreate/gMax1.5+/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/makibox/Configuration_adv.h b/Marlin/src/config/examples/makibox/Configuration_adv.h
index 24542edf5c..6aeb06c29d 100644
--- a/Marlin/src/config/examples/makibox/Configuration_adv.h
+++ b/Marlin/src/config/examples/makibox/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/tvrrug/Round2/Configuration_adv.h b/Marlin/src/config/examples/tvrrug/Round2/Configuration_adv.h
index de81492838..a25aa195ac 100644
--- a/Marlin/src/config/examples/tvrrug/Round2/Configuration_adv.h
+++ b/Marlin/src/config/examples/tvrrug/Round2/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/config/examples/wt150/Configuration_adv.h b/Marlin/src/config/examples/wt150/Configuration_adv.h
index 44867e7e08..e56be25e8f 100644
--- a/Marlin/src/config/examples/wt150/Configuration_adv.h
+++ b/Marlin/src/config/examples/wt150/Configuration_adv.h
@@ -243,6 +243,10 @@
   #define CASE_LIGHT_DEFAULT_ON true          // Set default power-up state on
   #define CASE_LIGHT_DEFAULT_BRIGHTNESS 105   // Set default power-up brightness (0-255, requires PWM pin)
   //#define MENU_ITEM_CASE_LIGHT              // Add a Case Light option to the LCD main menu
+  //#define CASE_LIGHT_USE_NEOPIXEL           // Use Neopixel LED as case light, requires NEOPIXEL_LED.
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+    #define CASE_LIGHT_NEOPIXEL_COLOR { 255, 255, 255, 255 } // { Red, Green, Blue, White }
+  #endif
 #endif
 
 //===========================================================================
diff --git a/Marlin/src/feature/caselight.cpp b/Marlin/src/feature/caselight.cpp
index 5cb00a5285..e2cc23368a 100644
--- a/Marlin/src/feature/caselight.cpp
+++ b/Marlin/src/feature/caselight.cpp
@@ -27,6 +27,17 @@
 uint8_t case_light_brightness = CASE_LIGHT_DEFAULT_BRIGHTNESS;
 bool case_light_on = CASE_LIGHT_DEFAULT_ON;
 
+#if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+  #include "leds/leds.h"
+  LEDColor case_light_color =
+    #ifdef CASE_LIGHT_NEOPIXEL_COLOR
+      CASE_LIGHT_NEOPIXEL_COLOR
+    #else
+      { 255, 255, 255, 255 }
+    #endif
+  ;
+#endif
+
 /**
  * The following are needed because ARM chips ignore a "WRITE(CASE_LIGHT_PIN,x)" command to the pins that
  * are directly controlled by the PWM module. In order to turn them off the brightness level needs to be
@@ -34,32 +45,39 @@ bool case_light_on = CASE_LIGHT_DEFAULT_ON;
  * to save it.
  */
 uint8_t case_light_brightness_sav;   // saves brighness info so can restore when "M355 S1" received
-bool case_light_arg_flag;  // flag to notify if S or P arguement type
+bool case_light_arg_flag;  // flag to notify if S or P argument type
 
 #ifndef INVERT_CASE_LIGHT
   #define INVERT_CASE_LIGHT false
 #endif
 
 void update_case_light() {
-  SET_OUTPUT(CASE_LIGHT_PIN);
 
   if (!(case_light_arg_flag && !case_light_on))
-    case_light_brightness_sav = case_light_brightness;  // save brightness except if this is an S0 arguement
+    case_light_brightness_sav = case_light_brightness;  // save brightness except if this is an S0 argument
   if (case_light_arg_flag && case_light_on)
-    case_light_brightness = case_light_brightness_sav;  // restore last brightens if this is an S1 arguement
+    case_light_brightness = case_light_brightness_sav;  // restore last brightens if this is an S1 argument
 
-  if (case_light_on) {
+  const uint8_t i = case_light_on ? case_light_brightness : 0, n10ct = INVERT_CASE_LIGHT ? 255 - i : i;
+
+  #if ENABLED(CASE_LIGHT_USE_NEOPIXEL)
+
+    leds.set_color(
+      MakeLEDColor(case_light_color.r, case_light_color.g, case_light_color.b, case_light_color.w, n10ct),
+      false
+    );
+
+  #else // !CASE_LIGHT_USE_NEOPIXEL
+
+    SET_OUTPUT(CASE_LIGHT_PIN);
     if (USEABLE_HARDWARE_PWM(CASE_LIGHT_PIN))
-      analogWrite(CASE_LIGHT_PIN, INVERT_CASE_LIGHT ? 255 - case_light_brightness : case_light_brightness);
-    else
-      WRITE(CASE_LIGHT_PIN, INVERT_CASE_LIGHT ? LOW : HIGH);
-  }
-  else {
-    if (USEABLE_HARDWARE_PWM(CASE_LIGHT_PIN))
-      analogWrite(CASE_LIGHT_PIN, INVERT_CASE_LIGHT ? 255 : 0);
-    else
-      WRITE(CASE_LIGHT_PIN, INVERT_CASE_LIGHT ? HIGH : LOW);
-  }
+      analogWrite(CASE_LIGHT_PIN, n10ct);
+    else {
+      const bool s = case_light_on ? !INVERT_CASE_LIGHT : INVERT_CASE_LIGHT;
+      WRITE(CASE_LIGHT_PIN, s ? HIGH : LOW);
+    }
+
+  #endif // !CASE_LIGHT_USE_NEOPIXEL
 }
 
 #endif // HAS_CASE_LIGHT
diff --git a/Marlin/src/feature/caselight.h b/Marlin/src/feature/caselight.h
index 5b6196d0dd..3e16819eb5 100644
--- a/Marlin/src/feature/caselight.h
+++ b/Marlin/src/feature/caselight.h
@@ -26,7 +26,7 @@
 extern uint8_t case_light_brightness;
 extern bool case_light_on;
 extern uint8_t case_light_brightness_sav;   // saves brighness info when case_light_on is false
-extern bool case_light_arg_flag;  // flag to notify if S or P arguement type
+extern bool case_light_arg_flag;  // flag to notify if S or P argument type
 
 void update_case_light();
 
diff --git a/Marlin/src/feature/leds/leds.h b/Marlin/src/feature/leds/leds.h
index f5194a260f..fe00cd3c48 100644
--- a/Marlin/src/feature/leds/leds.h
+++ b/Marlin/src/feature/leds/leds.h
@@ -70,6 +70,21 @@ typedef struct LEDColor {
       #endif
     #endif
   {}
+  LEDColor(const uint8_t (&rgbw)[4]) : r(rgbw[0]), g(rgbw[1]), b(rgbw[2])
+    #if HAS_WHITE_LED
+      , w(rgbw[3])
+      #if ENABLED(NEOPIXEL_LED)
+        , i(NEOPIXEL_BRIGHTNESS)
+      #endif
+    #endif
+  {}
+  LEDColor& operator=(const uint8_t (&rgbw)[4]) {
+    r = rgbw[0]; g = rgbw[1]; b = rgbw[2];
+    #if HAS_WHITE_LED
+      w = rgbw[3];
+    #endif
+    return *this;
+  }
   LEDColor& operator=(const LEDColor &right) {
     if (this != &right) memcpy(this, &right, sizeof(LEDColor));
     return *this;
diff --git a/Marlin/src/inc/SanityCheck.h b/Marlin/src/inc/SanityCheck.h
index c169cf0d27..0821082d8b 100644
--- a/Marlin/src/inc/SanityCheck.h
+++ b/Marlin/src/inc/SanityCheck.h
@@ -1549,6 +1549,10 @@ static_assert(COUNT(sanity_arr_3) <= XYZE_N, "DEFAULT_MAX_ACCELERATION has too m
   #error "LED_CONTROL_MENU requires an LCD controller."
 #endif
 
+#if ENABLED(CASE_LIGHT_USE_NEOPIXEL) && DISABLED(NEOPIXEL_LED)
+  #error "CASE_LIGHT_USE_NEOPIXEL requires NEOPIXEL_LED."
+#endif
+
 #if ENABLED(SKEW_CORRECTION)
   #if !defined(XY_SKEW_FACTOR) && !(defined(XY_DIAG_AC) && defined(XY_DIAG_BD) && defined(XY_SIDE_AD))
     #error "SKEW_CORRECTION requires XY_SKEW_FACTOR or XY_DIAG_AC, XY_DIAG_BD, XY_SIDE_AD."